A group of researchers believes that they’ve found a specific place in the human genome that contributes to the risk of erectile dysfunction in men. Scientists from the Kaiser Permanente, one of the biggest managed care organization in the U.S., have possibly identified variations in the genetic locus, found near the SIM1 gene, were associated with 26 percent increased risk of the condition.
“Distinguishing this SIM1 locus as a risk factor for erectile dysfunction is a major ordeal since it gives the long sought-after proof that there is a hereditary component to the condition,” said Eric Jorgenson, a researcher at the varsity. “Identifying the first risk factor for erectile dysfunction is an energizing disclosure since it opens the door for examinations concerning new, hereditary based treatments.”
For the investigation, published in the diary Proceedings of the National Academy of Sciences, nearly 222,358 men were included. The discoveries uncovered that the SIM1 locus was indeed a risk factor for erectile dysfunction, regardless of whether the disease was characterized through clinical diagnoses, medical history, or study member self-report.
The study features the capability of SIM1 as a target for the development of new medicines for erectile dysfunction, which is required on the grounds that about half of all men who try currently available pharmaceutical medications for erectile dysfunction do not respond to them.
Treatments dependent on these variables exist, yet many men do not respond to them, the scientists said. Hereditary components are additionally suspected as a factor in around 33% of erectile dysfunction cases, yet scientists have failed to make an association with a particular genomic area until now.
“This discovery focuses on to another research direction for erectile dysfunction that could enable us to distinguish other key hereditary components that trigger the disorder and lead to examinations to better comprehend the exact mechanisms by which they work,” clarified Hunter Wessells, at the University of Washington.